Colchicum Autumnale Extract Colchicine

Botanical Name: Colchicum Autumnale
Part Used: Flower, Leaf
Active ingredients: Colchicine
Appearance: Yellow Powder
Specification: 98% by HPLC
Package: 25kg/drum

What is Colchicum Autumnale Extract Colchicine?

Colchicum autumnale, commonly known as autumn crocus, meadow saffron or naked lady, is an autumn-blooming flowering plant that resembles the true crocuses, but is a member of the Colchicaceae plant family, unlike the true crocuses which belong to the Iridaceae family. The name “naked lady” comes from the fact that the flowers emerge from the ground long after the leaves have died back.

Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum. Adverse effects are primarily gastrointestinal upset at high doses. The chemical name for colchicine is (S)-N-(5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9 oxobenzol[a]heptalen-7-yl) acetamide.

Health Benefits of Colchicum Autumnale Extract Colchicine

Colchicum Autumnale Extract Colchicine is used to prevent or treat gout attacks (flares). Usually gout symptoms develop suddenly and involve only one or a few joints. The big toe, knee, or ankle joints are most often affected. Gout is caused by too much uric acid in the blood. When uric acid levels in the blood are too high, the uric acid may form hard crystals in your joints. Colchicine works by decreasing swelling and lessening the build up of uric acid crystals that cause pain in the affected joint(s).

This medication is also used to prevent attacks of pain in the abdomen, chest, or joints caused by a certain inherited disease (familial Mediterranean fever). It is thought to work by decreasing your body’s production of a certain protein (amyloid A) that builds up in people with familial Mediterranean fever.

Colchicine is not a pain medication and should not be used to relieve other causes of pain.

Dosage of Colchicum Autumnale Extract Colchicine

Colchicine 1 to 2 mg is a typical oral dose for gout, corresponding to crocus seed 200 mg or corm 250 mg. Colchicine also has been studied for osteoarthritis of the knee, refractory constipation, and postpericardiotomy syndrome at similar doses. Its narrow therapeutic index requires medical supervision. However, autumn crocus has not been studied at these doses for verification.

Potential Side Effects Of Colchicum Autumnale Extract Colchicine

Gastrointestinal disorders are the most common adverse reactions with colchicine. They are often the first signs of toxicity and may indicate that the colchicine dose needs to be reduced or therapy stopped. These include diarrhea, nausea, vomiting, and abdominal pain.

Colchicine has been reported to cause neuromuscular toxicity, which may present as muscle pain or weakness.

Toxic manifestations associated with colchicine include myelosuppression, disseminated intravascular coagulation, and injury to cells in the renal, hepatic, circulatory, and central nervous system. These most often occur with excessive accumulation or overdosage.

Certificate of Analysis

ITEM SPECIFICATION METHOD RESULT
Assay Colchicine 99% HPLC Complies
Appearance Yellow powder N/A Complies
Particle size 100% pass 80 mesh USP32<786> Complies
Extract Solvents Water/Ethanol N/A Complies
Identification Positive Reaction N/A Complies
Tests
Loss on Drying ≤5.0% Eur.Ph.6.0[2.8.17] Complies
Acid-insoluble ash ≤7.0% Eur.Ph.6.0[2.4.16] Complies
Lead(Pb) ≤1.0mg/kg Eur.Ph6.0<2.2.58>ICP-MS Complies
Arsenic(As) ≤1.0mg/kg Eur.Ph6.0<2.2.58>ICP-MS Complies
Cadmium(Cd) ≤1.0mg/kg Eur.Ph6.0<2.2.58>ICP-MS Complies
Mercury(Hg) ≤1.0mg/kg Eur.Ph6.0<2.2.58>ICP-MS Complies
Solvents Residue Meet Eur.Ph6.0<5.4> Eur.Ph 6.0<2.4.24> Complies
Pesticides Residue Negative USP32<561> Complies
Microbiological Control
Total bacterial count ≤1000cfu/g USP30<61> Complies
Yeast & mold ≤100cfu/g USP30<61> Complies
Salmonella Negative USP30<62> Complies
E.Coli Negative USP30<62> Complies

Flowchart of Production

flowchart

Package for Colchicum Autumnale Extract Colchicine

packing

Shipping for Colchicum Autumnale Extract Colchicine

  • By Express: Suitable for under 50kg, 5-10 days
  • By Air: Suitable for more than 50kg, 7-15 days
  • By Sea: Suitable for more than 500kg, 15-45days

Why Choose FYZ Colchicum Autumnale Extract Colchicine?

  • FYZ is a professional Colchicum Autumnale Extractmanufacturer in China, provides OEM service.
  • FREE SAMPLE with freight collection (5-10g) for detection, if you need more, please contact us.
  • Fast delivery by DHL/FedEx, air as your requirement.
  • All of our products from nature, no additive.
  • Money refund policy.

Inquiry